-DHODH inhibitors prevent de novo pyrimidine synthesis (138)-Lefunomide is approved for the treatment of rheumatoid arthritis and psoriatic arthritis (138)-Teriflunomide is approved for the treatment of patients with relapsing forms of multiple sclerosis (138)-DHODH inhibition enhances tumor cell antigen presentation and response to immune checkpoint blockade (144)-DHODH inhibitors tune the developmental trajectory of immunization-elicited T cells elicited from predominantly short-lived effectors to a memory phenotype (145). Here, DHODH is linked to multiple sclerosis.