Enzymatic degradation of hyaluronan using PEGylated recombinant human hyaluronidase (PEGPH20) has been shown to enhance the uptake of checkpoint inhibitors in the TME, increase infiltration of CD8+ T cells and NK cells into tumor tissue, reduce MDSC numbers, and lead to improved tumor growth suppression in vivo (Singha et al., 2015; Clift et al., 2019). This evidence concerns the gene CD8A and neoplasm.