TGFB1 and neoplasm: At the same time, it should be noted that direct manipulation of the tumor ECM, for example, through blockade of TGF-β or MMPs, may prove unsuccessful due to serious side effects associated, among others, with disruption of normal tissue homeostasis (Krüger et al., 2010; Colak and ten Dijke, 2017; Winer et al., 2018; Teixeira et al., 2020).