TGF-β, in turn, skews the polarization of nonactivated neutrophils and macrophages towards phenotypes similar to N2 (tumor-associated neutrophils, TANs) and similar to M2 (tumor-associated macrophages, TAMs), respectively (Fridlender et al., 2009; Zhang et al., 2016). The gene discussed is TGFB1; the disease is neoplasm.