Despite the evidence supporting distinct roles for DYRK1A in immune and inflammatory pathologies, the authors did not observe positive correlations between DYRK1A and multiple inflammatory pathways and immune markers (such as CSTB, C-reactive protein or IL-6), suggesting a minor role for DYRK1A in chronic interferon hyperactivity and inflammation in people with DS. This evidence concerns the gene DYRK1A and Dravet syndrome.