DYRK1A and autoimmune disease: In a previous study, this group had confirmed that NFATc1 signaling is crucial for Treg differentiation in this model and observed that increased DYRK1A and GSK3B transcripts lead to decreased NFATc1 activity, which is responsible for reduced Treg suppressive capacity (Giri et al., 2022), thus highlighting the role of DYRK1A in autoimmune disease severity and progression.