Consequently, they proposed that the combination of vilanterol and STING agonists sensitizes PDAC to CLDN18.2-targeted BiTE therapy, enhancing its efficacy as a promising new strategy (Zhou et al., 2024b).In summary, these studies have validated the utility of organoid technology for investigating tumor heterogeneity, paving the way for establishing a living biobank of multiple patients’ tumor tissues to study individual pathogenic mechanisms, which is crucial for targeted research and personalized drug testing (Magré et al., 2023). The gene discussed is STING1; the disease is neoplasm.