Based on genome-wide CRISPR-Cas9 screening, Zhang et al. found that C-C motif chemokine receptor 2 (CCR2) enhances SFTSV binding by directly binding to SFTSV Gn, and knockout of CCR2 gene greatly reduces viral binding and infection, this suggests that CCR2 is the host entry receptor for SFTSV infection [70]. Here, CCR2 is linked to infection.