RPS6KA3 and posterior cortical atrophy: Also, it has been reported that the oncogenic function of RSK1 in PCa is attributed to the activation of an RSK-dependent transcriptional program, which is exemplified by the ability of RSK1/2 to directly phosphorylate and regulate TF CREB and c-Fos, hence initiating a cascade of the downstream signaling pathway (28, 29).