Infusion of ANG II during pregnancy has been shown to mimic preeclampsia/maternal hypertension-like phenotypes in rats, including increased BP, albuminuria, shallow trophoblast invasion accompanied by a reduced percentage of remodeled spiral arteries in the decidua, systemic inflammation, and reduced placental perfusion and intrauterine growth restriction (35, 37–39). Here, AGT is linked to fetal growth restriction.