Our preclinical results are consistent with those obtained with other preeclampsia and maternal hypertension models, for example, those induced by transgenic means (indoleamine 2,3-dioxygenase knockout) or by infusion of vasopressin or N(ω)-nitro-l-arginine methyl ester (34, 35, 41–44). The gene discussed is IDO2; the disease is preeclampsia.