Among multiple expanded pathogenic polyQ transgenes, we selected spinocerebellar ataxia type 3 (SCA3; also known as Machado-Joseph disease, MJD-78Q) for analysis, as prior work demonstrated that UAS-MJD-78Q expression most severely disrupts the dendritic arborization of class IV neurons [19]. This evidence concerns the gene ATXN3 and Machado-Joseph disease.