CYP2E1 and Nephropathy: Due to its capacity to induce oxidative damage, CCl4 is frequently employed as an experimental model for studying oxidative stress‐related pathologies.[5] CCl4 can induce severe renal injury in rats by impairing the antioxidant defense system, potentially resulting in nephropathies.[6] During biotransformation by cytochrome P450 enzymes, primarily cytochrome P450 2E1 (CYP2E1), CCl4 is converted into the highly reactive trichloromethyl radical (•CCl3).