We hypothesize that obesity modulates histone H3K27 marks, modified by demethylases (lysine‐specific demethylase 6A and 6B [KDM6A/KDM6B]) and acetylases (CREB–binding protein [CREBBP]/histone acetyltransferase EP300), affecting ASC function. The gene discussed is CREBBP; the disease is Obesity.