We then hypothesized that leptin, highly elevated in patients with obesity and, in our studies, markedly correlated with higher CCL2/MCP‐1 expression in both plasma and vWAT, as well as in ASCs, increases the expression of this chemokine in ASCs by regulating H3K27 acetylation. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.