As expected, patients with obesity (Groups II and III) showed significant elevations in plasma levels of triglycerides, nonesterified fatty acids, and inflammatory markers such as CCL2/MCP‐1, TNF‐α, plasma endotoxin (LPS), and LEP, along with a very significant increase in adipocyte size. This evidence concerns the gene CCL2 and obesity due to melanocortin 4 receptor deficiency.