The literature highlights that obesity‐related complications are closely linked to the expansion of WAT, characterized by hypertrophic adipocytes and the infiltration of inflammatory cells, particularly M1 macrophages, which increase CCL2 expression, promoting inflammation and insulin resistance, a precursor to type 2 diabetes [27, 33, 34]. This evidence concerns the gene CCL2 and obesity due to melanocortin 4 receptor deficiency.