In this study, we demonstrate a role for cyclin–CDK1 complexes in regulating cell migration in normal RPE1 cells in addition to invasive migration in ovarian and BC cells, suggesting that modulation of cyclinA2, cyclinB1 and CDK1 expression or cyclin–CDK1 complex activity might contribute to the acquisition of invasive capabilities in cancer cells. Here, CDK1 is linked to breast cancer.