This analysis yielded a family of BGCs, presentin both Penicillium paradoxum (lig BGC) and Botryosphaeria dothidea (bdlig BGC) (Figure A) containing a core nonreducing polyketide synthase(NRPKS, Figure S1A) gene and a homologof RPL10 (also recognized as ul16), the gene for large-subunit ribosomal protein RPL10, which, whenoverexpressed, is reported to play a role in the proliferation ofovarian and pancreatic cancers., Canonically, ribosomalprotein genes are not present in BGCs, making this a strong candidatefor a resistance gene. Here, RPL10 is linked to familial pancreatic carcinoma.