PTEN and central nervous system cancer: EGFR amplification and PTEN loss particularlyco-occur in GB. IQGA1, the only proteinsignificantly overexpressed in GB CL compared to the pool of otherHGG, is involved in cell adhesion and migration of glioma cells, andits expression correlates with poor tumor grade and survival. It is a known scaffold protein in glioma stemcell niches.