ALDOC and colorectal carcinoma: As illustrated in Fig. 6A and B and S6, CRC cells with ALDOC knockdown exhibited significantly lower levels of ATP content, glucose uptake, and lactate production compared to shCtrl cells, alongside a decrease in extracellular acidification rate (ECAR) and an increase in oxygen consumption rate (OCR), indicating a notable regulatory effect of ALDOC on aerobic glycolysis in CRC cells.