ALDOC and malignant colon neoplasm: Importantly, in an association study of BRD9 with colon cancer conducted by Zhu et al., they found that the promoting effect of BRD9 on glucose metabolism reprogramming and tumor progression of colon cancer was partially derived from the enhanced acetylation modification of H3K27 in the ALDOC promoter region and the resulting transcriptional activation of ALDOC (Zhu et al. 2023).