IGF2 overexpression in the IC1 subtype demonstrated striking nephromegaly [29], and the downregulation of p57KIP2 in the IC2 subytpe (loss of KvDMR1 methylation which might downregulate p57KIP2 expression) produced cystic renal disease [12]. The gene discussed is KCNQ1OT1; the disease is Enlarged kidney.