High-level HMGA2 staining was associated with invasive tumor growth of urinary bladder cancers (p < 0.0001); high-grade, advanced pT, metastasis, and poor overall survival (p < 0.0001 each) in clear cell renal cell carcinoma (RCC); nodal metastasis in papillary RCC (p = 0.0099); as well as nodal metastasis in papillary thyroid cancer (p = 0.0063). The gene discussed is HMGA2; the disease is clear cell renal carcinoma.