The mutational profile of DLBCL transformed from NLPB/HL shows alterations in genes of the NF‐kB (SGK1, CARD11, JUNB) and chromatin modification pathways, as well as frequent mutations in genes like TET2, JUNB, and NOTCH2, which are rare in de novo DLBCLs [37], and resembles the mutations of the ST2 subgroup of the LymphGen DLBCL genomic classification [38], Harvard's cluster 4 [39] and the TET2/SGK1 subgroup of the modified HMRN classification [40]. Here, NOTCH2 is linked to diffuse large B-cell lymphoma.