Notably, the H-CRS group exhibited higher expression levels of Macrophages M0 and NK cells (Fig. 8B).The infiltration of activated mast cells, T cells regulatory and CD8 + T cells in the tumor microenvironment of patients in the high-risk group increased significantly, indicating that these patients have a more active immune microenvironment, which may affect the efficacy of immunotherapy. The gene discussed is CD8A; the disease is neoplasm.