DNA was extracted from 96 blood samples collected from patients attending Tertiary cardiovascular centers for treatment of CAD in Cairo’s Kobri ElKoba hospital and Alexandria’s Main University hospitals and analyzed for variants in coding sequence of LDLR, PCSK9, APOB, APOE, LDLRAP1, ABCG5 and ABCG8 using NGS. The gene discussed is PCSK9; the disease is coronary artery disorder.