PNP and hyperinsulinemic hypoglycemia, familial, 4: PNP deficiency in human induced severe T-cell dysfunction,20 and PNP inhibitors have been employed as selective immunosuppressive agents for T-cell malignancies and T-cell mediated autoimmune diseases.25 However, little is known about the potential roles of PNP-mediated salvage pathway in the viral-host interplay during IAV infection.