KRAS and non-small cell lung carcinoma: They found that KRT8-high expressing and driver KRAS-mutated cells are involved in the further development of lung cancer following tobacco carcinogen exposure.83 Similarly, scRNA-seq of NSCLC showed that poor prognosis is highly correlated with a subset of regulatory T cells expressing IL-1R2.84 However, gene variation markers for a specific cell type (or cell state) are almost never exclusive to those cells.