MBD2 and non-small cell lung carcinoma: EZH2 induces condensation of chromatin, thereby inhibiting the transcription of tumor suppressor genes.71 A bioinformatic analysis of methyltransferases and demethylases in NSCLC using TCGA and cBioportal databases showed that H3K27 methyltransferase EZH2 was significantly up-regulated while H3K27 demethylase KDM6B was significantly down-regulated in lung cancer.