EGFR and cancer: By investigating the expression of 207 miRNAs in various cancer cell lines, Park SM et al. identified the miR-200 family as representative markers for cells with epithelial phenotype, which could directly target the mRNA of ZEB1 and ZEB2 (E-cadherin transcriptional repressors), leading to the up-regulation of E-cadherin, thus inhibiting the EMT process.93 In EGFR-mutated cancers, members in miR-200 family have also been reported to be downregulated, thus enhance the drug resistance and EMT characteristics of NSCLC.