Zhang et al. analyzed EGLN DNA methylation data from the tumor tissue samples of 1230 NSCLC patients, and the results showed that DNA methylation of EGLN2-HIF (hypoxia-inducible factor)1a affects the prognosis of NSCLC.67 SORT1 is downregulated in NSCLC and its epigenetic irregularities, especially DNA methylation level, is related to patients’ survival. This evidence concerns the gene EGLN2 and non-small cell lung carcinoma.