The primary mechanisms for repairing these DSBs involve non-homologous end joining (NHEJ) or high-fidelity homologous recombination repair.171 Consequently, mutations in DNA damage repair pathways, including TP53, KEAP1, NFE2L2, KMT2C, and KMT2D, are significantly correlated with notable radioresistance in NSCLC. The gene discussed is TP53; the disease is non-small cell lung carcinoma.