Furthermore, copy number variations and missense of other methyltransferases and demethylases were also detected in lung cancer patients, such as PRDM9, SETD1A, SMYD3, KDM5A and KDM5B.72 Taken together, the above research implicates that epigenetic alterations affect the key molecules involved in NSCLC and play an important role in tumorigenesis. This evidence concerns the gene MBD2 and lung cancer.