Alteration of HIF by EGFR signaling could further promote the EMT transformation.92 The overexpression of EML4-ALK in NSCLC cell line induces the EMT phenotype, and upregulates the expression of EMT-related transcription factors, which could be reversed by an inhibition of ERK1/2. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.