More than 200 BRAF mutations have been identified, predominantly occurring at the 600th codon (where approximately 50% are V600E and the others include V600K, V600D, V600R, and V600M mutations),51 which are found in approximately 1–2% of NSCLC, comprising 30–50% of all BRAF mutations. This evidence concerns the gene BRAF and non-small cell lung carcinoma.