ImmunoTar analysis identified CSPG4, CSPG5, TGFBR3, SDC1, SDC2, SDC3, PTPRZ1, GPC2, and PLG as the highest-ranking extracellular matrix-associated proteins with strong potential as immunotherapy targets in pediatric high-grade gliomas (Fig. 1B). Here, CSPG5 is linked to central nervous system cancer.