We speculate that CXCL12-positive fibroblasts in the lower dermis are important for initial neutrophil infiltration into the skin and that fibroblasts located in the upper dermis express CXCL1-8 to further recruit cells to the papillary dermis, where neutrophils commonly reside in patients with SS. The gene discussed is CXCL1; the disease is synovial sarcoma.