Psoriasis vulgaris skin cell atlas studies have resolved IAF subsets expressing neutrophil chemokines that bind CXCR2 and CXCR4.18,25 Here, using a combination of subcellular resolution spatial transcriptomics and immunostaining, we identified 2 distinct neutrophil chemokine-expressing fibroblast populations: a neutrophil-proximal subset expressing CXCR2 ligands in the upper dermis and a neutrophil-distal subset expressing the CXCR4 ligand CXCL12 in the lower dermis. Here, CXCR2 is linked to psoriasis vulgaris.