Footprinting analysis42 on our ATAC-seq data revealed a 43.8% higher number of bound ZBTB7A sites in non-neuronal vs. neuronal cells, with a 3.4-fold increase in occupied ZBTB7A sites identified in non-neuronal MDD samples compared to controls––making it one of the top five most differentially bound TFs genome-wide (Figure 2H,I). The gene discussed is ZBTB7A; the disease is major depressive disorder.