However, it is well documented that PC3 cells do not secret IL-2 [24] and our gene correlation analysis using GEPIA also confirms that there is no gene expression correlation between P2RX4 and IL-2 in prostate adenocarcinoma (Supplementary Fig. 3e) but a positive correlation in whole blood (Supplementary Fig. 3f). This evidence concerns the gene P2RX4 and prostate adenocarcinoma.