Zhou and co-workers introduced such a strategy for detectingalpha-fetoprotein, a tumor protein biomarker. The mechanism relied on the aggregation of antibody-functionalized(anti-alpha-fetoprotein) AgNPs in the presence of alpha-fetoprotein.In this case, the thicker particle corona generally leads to lowerpeak amplitudes (Figure a) but simultaneously results in increased colloidal stability. This evidence concerns the gene AFP and neoplasm.