mRNA-2416 is a novel lipid nanoparticle-encapsulated mRNA encoding human OX40L, which was developed for intratumoral injection (Figure 1).9 Induction of OX40L within the tumor microenvironment through direct injection of mRNA-2416 has the potential to restore OX40 receptor engagement and enhance antitumor immunity through stimulation of tumor-specific T-cell activation, resulting in local and systemic antitumor responses. The gene discussed is TNFSF4; the disease is neoplasm.