TGFB1 and neoplasm: Beyond these contacts, platelets discharge a suite of growth-promoting cytokines and chemokines, such as tumor growth factor-β (TGF-β) [15, 16], vascular endothelial growth factor (VEGF) [17], platelet-derived growth factor (PDGF) [18], and platelet factor 4 (PF4) [19] that further fuel tumor expansion.