CCNB1 and neoplasm: In the field of oncology research, the transcription factor FOXM1 is extensively documented as a regulator of numerous downstream genes, which are involved in various aspects such as cell cycle regulation ( CCNB1, CCNB2), angiogenesis (VEGF), and antioxidant defense (SOD) [50, 51].Taking breast cancer as an example, FOXM1’s promotion of intratumoral blood vessel generation through upregulating VEGF expression unveiled its pivotal role in tumor progression [52].