However, where RNA VAF disagreed with BoostDM, gene set activity suggested that RNA VAF results tended to be more consistent with tumor phenotype than BoostDM (i.e., in BoostDM passengers that were RNA VAF drivers, H3K27me3 activity was similar to BoostDM drivers that were RNA VAF drivers; while in BoostDM drivers that were RNA VAF passengers, H3K27me3 activity was more similar to non-KDM6A-mutated tumors). Here, KDM6A is linked to neoplasm.