Within tumors containing a BoostDM EGFR driver mutation and an RNA VAF > 0.9, ssGSEA (single sample gene set enrichment analysis) revealed significantly higher expression of the REACTOME “EGFR signalling in cancer” gene set, when compared to BoostDM driver mutations with an RNA VAF < 0.1 (P = 0.025, Fig. 5C). Here, EGFR is linked to cancer.