Furthermore, connexins—key mediators of intercellular communication—have been implicated in the proarrhythmic effects associated with renal dysfunction (Sidaway 2014; Sinha et al. 2023; Price et al. 2020), with TGF-β signaling playing a central role (Potter et al. 2021). The gene discussed is TGFB1; the disease is Abnormal renal physiology.