Similarly, the European Group for the Study of Insulin Resistance (EGIR) centres insulin resistance in MetS pathophysiology but uses an alternative definition.4 EGIR characterises insulin resistance as ‘a fasting plasma insulin value that is greater than the 75th percentile' (1999).4 This acts as an easier diagnostic tool; however, it fails to consider type 2 diabetics (as fasting insulin is not an appropriate measurement), thus making this definition somewhat over-simplistic. The gene discussed is INS; the disease is metabolic syndrome.