The primary aetiology of MetS is thought to be via the pro-inflammatory response, which can occur as a result of insulin resistance: a condition characterised by inefficient binding of insulin to fat, muscle and liver cells, resulting in poor glucose uptake.14 Specifically, increased presence of inflammatory cytokines, such as C-reactive protein and interleukin-6, significantly increase insulin resistance. The gene discussed is INS; the disease is Insulin resistance.