All patients experienced ≥1 TRAE, most common being neutropenia, peripheral neuropathy, thrombocytopenia, nausea, fatigue, anemia, diarrhea, vomiting, hypomagnesaemia, increased aspartate aminotransferase and alanine aminotransferase, and alopecia. The gene discussed is GPT; the disease is Decreased total neutrophil count.