There was a significant difference between the three cohorts regarding CSF SERPIN E1 levels with the highest levels in DLB total cohort (986.6 pg/ml (±747.5)), followed by PD total cohort (726.0 pg/ml (±415.0)) and CON (687.6 pg/ml (±326.1)) (p ≤ 0.001). Here, SERPINE1 is linked to Lewy body dementia.