Specifically, there are 6 base substitutions in the 30 bases of the attenuator loop sequence (80.00% homology) and only 1 substitution in the remaining 89 bases of the -1 FSE sequence (98.88% homology).16 As previously noted, -1 PRF RNA has been considered a potential breakthrough target for treating COVID-19.10 To date, only a few host factors, including SFL,18 ZAP-S,19 and eIF2A,20 have been identified as participants in the regulating SARS-CoV-2 programmed -1 ribosomal frameshifting. This evidence concerns the gene EIF2A and COVID-19.