APPL1 and Alzheimer disease: Alteration of hippocampal synaptic plasticity has been shown in AD-related mouse models (Marchetti and Marie, 2011; Dietrich et al., 2018), and APPL1 has been shown to be a regulator of hippocampal synaptic plasticity (Fernandez-Monreal et al., 2016; Wang et al., 2016; Formolo et al., 2022; Hua et al., 2023).