A total of 2169 ANA+ and 5118 ANA− individuals were included in the meta-analysis; only one variant upstream of TSBP1 within the HLA locus on chromosome 6, rs1967688, was associated with ANA+ (p=4.8×10−8), and this SNP was significantly associated with SLE in European populations (p=1.6×10−9, online supplemental table S5). This evidence concerns the gene TSBP1 and systemic lupus erythematosus.