SCARB1 and atherosclerosis: In contrast to ApoE KO and Ldlr KO mice, which lack atherosclerosis in their coronary arteries, double-mutant SR-BIΔCT/ΔCT;Ldlr KO mice (hereon called ‘DM mice’) containing a three amino-acid deletion at the C-terminus of SR-B1 and lacking Ldlr do develop atherosclerosis in their coronary arteries when fed an atherogenic diet.22 However, their response to I/R injury and cardioprotective strategies has not previously been investigated.