In contrast to RIC, 1938 was cardioprotective in DM mice, to a similar extent as we previously found in WT mice.30 We interpret this result as indicating that compounds such as 1938 that are able to bypass cell-surface receptors and/or dysfunctional endothelium, and directly activate PI3Kα in the myocardium, might be more effective in the clinical scenario. The gene discussed is CD177; the disease is diabetes mellitus.