In myocardial ischemia/reperfusion (I/R) injury, CCR2+ myocardial-resident macrophages promote the recruitment and infiltration of CCR2+ monocytes via the MyD88-dependent pathway, sustaining a strong inflammatory response that exacerbates myocardial damage and contributes to the malprogression of left ventricular remodeling [70]. The gene discussed is MYD88; the disease is myocardial ischemia.