APOE and Alzheimer disease: Our data and the rpAD cohorts investigated independently in the centers in Germany, Japan, Spain, and France in the past decade demonstrated uniform NIA-AA neuropathological characteristics, low frequency of e4 alleles in the APOE gene, higher frequency of novel loci in AD risk genes while the autosomal dominant history of dementia or comorbidity is absent [3,4,6,7,9–14].