TARDBP and hippocampal atrophy: They found more pronounced hippocampal atrophy in LATE-NC compared with non-LATE-NC AD donors.15-18 More specifically, MRI volume and TDP-43 pathology were negatively associated in the anterior hippocampus18 and cornu ammonis (CA) 1 region, indicating hippocampal (subfield) volume as a potential marker for LATE-NC.15 Intervals of several years can limit the interpretation of post-mortem immunohistochemistry measures to in vivo MRI data, because disease progression may obscure the role of LATE-NC pathology in the neurodegenerative process.