TARDBP and Alzheimer disease: Little is known about relative TDP-43 burden in amygdalar subnuclei, but TDP-43 burden in the subiculum, CA1 and dentate gyrus in LATE-NC has been reported in several studies.12,51,52 Interestingly, Uemura et al.12 report differences in distribution of TDP-43 between LATE-NC AD and LATE-NC LBD in the hippocampus, including a relative increase in TDP-43 burden in the CA2 and CA3 in LATE-NC LBD.12 Although we report similar findings (Supplementary Fig. 3), this increase in CA2-3 density is mainly driven by two cases.