Several studies have used ex vivo post-mortem imaging of formalin-fixed brain tissue to investigate neuropathological correlates of amygdalar and hippocampal atrophy,19-21 and show that both p-tau and TDP-43 severity contribute to amygdalar and hippocampal volume loss.18,21 Moreover they show that TDP-43 burden associates with amygdalar and hippocampal shape distortion,19,21 suggesting that amygdalar and hippocampal subfields might be differently affected by LATE-NC pathology. Here, TARDBP is linked to hippocampal atrophy.