In the type 2-low asthma model, Sema3E-deficient mice exhibited increased tissue resistance and elastance, accompanied by elevated levels of neutrophils, dendritic cells, CD4 + T cells, and pro-inflammatory cytokines such as IL-17, TNF, IL-1β, CXCL-8, and MCP-1/CCL2. The gene discussed is TNF; the disease is asthma.