Moreover, the fact that Sema3E consistently showed the homeostatic and regulatory role across three different mouse strains (129P2 [22,25,26], C57BL/6 (unpublished data), and BALB/c [16,23]) and four different asthma models (acute (2 weeks) [16,23], chronic (11 weeks) [22], type 2-low (4 weeks), and type 2-high (4 weeks)) is notable. Here, SEMA3E is linked to asthma.