In the type-2 low asthma model, we observed a higher number of neutrophils (p < 0.0001), dendritic cells (DC) (p < 0.0001), and CD4 + T cells (p < 0.05) in Sema3E KO mice compared to WT mice (Fig 2E–2G). The gene discussed is SEMA3E; the disease is asthma.