The elevated IL-17 and CXCL8 levels in Sema3E KO mice in the type-2 low model further support its role in neutrophilic inflammation, not only in HDM asthma, as previously reported [20], but also in type-2 low asthma, where IL-17 and CXCL8 are key cytokines in neutrophil recruitment and activation in severe asthma [37]. Here, CXCL8 is linked to asthma.