CRP and obesity due to melanocortin 4 receptor deficiency: In 2006, the Camden Study reported women in the highest quintile of serum ferritin had a 2-fold increased risk of GDM, but the effect became non-statistically significant after additional adjustment for prepregnancy BMI or CRP [22], which suggested that low-grade inflammation or obesity may act as a partial mediating factor for the increased risk of GDM associated with an elevated serum ferritin level.