APP and Cognitive impairment: Such spontaneous activity, which relies on intact synaptic transmission,19 has been shown to integrate and represent sensory and multidimensional behavioral information,20 and subserves computational functions related to memory, learning, and decision-making.21,22 We hypothesized that APP family KO adversely impacts spontaneous neuronal activity in cortex and hippocampus, which reflects an underlying cellular/synaptic impairment that could in turn mechanistically underpin the wide-ranging behavioral and cognitive deficits previously observed in these animals.12