We selected these regions as APP family proteins are highly expressed in these areas under normal conditions, they corresponded to anatomical locations where the APP family was absent in excitatory neurons in cTKO mice, and include brain areas tightly linked to vulnerability to AD pathology.24,25 We observed that KO of the APP family within excitatory forebrain neurons resulted in a suppression of ongoing activity during awake rest and locomotion states as well as sleep-related slow-wave activity (SWA). Here, APP is linked to Alzheimer disease.