ACAN and myeloid sarcoma: Our data showed thatproteoglycan content in the ECM of the cartilage-like model decreasedafter 3 or 7 days of MS, which was accompanied by the release of GAGsinto the supernatant and an increase in the expression of ADAMTS5, a key enzyme involved in aggrecan degradation duringOA. Interestingly, HtrA1, a serine proteaseassociated with OA and ECM impairment, along with MMP activity, wasupregulated under MS.