According to the literature, LPAR1 is closely related to ovarian cancer, lung cancer, breast cancer, etc [25], but there is no report on thyroid tumors.Numerous previous studies have demonstrated that LPAR1-6 play pivotal roles in numerous core processes of tumorigenesis and progression via the MAPK pathway, including proliferation, survival, migration, invasion, metastasis, cancer stem cells, the tumor microenvironment, and therapeutic resistance [26, 27]. This evidence concerns the gene LPAR1 and cancer.