According to multinominal logistic regression analysis, with healthy controls used as the reference category, we also assessed the impact of clinical parameters on histological glioma type and found that the increase in serum GAL-8 levels (OR: 2.167, 95% CI: 1.126–4.172, p < 0.05) was a risk factor for GBM. Here, LGALS8 is linked to glioblastoma.