In the ROC analysis, the threshold values of the serum GAL-1, GAL-8, ITGβ-1, HIF-1α, and MMP-9 levels for diagnosing glioma were 41.83 ng/mL, 8.28 ng/mL, 436.34 pg/mL, 1411.00 pg/mL, and 450.08 ng/mL, respectively. Here, MMP9 is linked to central nervous system cancer.