In glioma patients, the AUCs for serum GAL-1, GAL-8, ITGβ-1, HIF-1α, and MMP-9 were 0.765 [95% CI (0.686–0.843), p < 0.01], 0.864 [95% CI (0.807–0.921), p < 0.01], 0.905 [95% CI (0.858–0.951), p < 0.01], 0.686 [95% CI (0.601–0.770), p < 0.01], and 0.852 [95% CI (0.791–0.913), p < 0.01], respectively. The gene discussed is HIF1A; the disease is central nervous system cancer.