LGALS1 and malignant glioma: Likewise, according to histological tumor type, the highest serum GAL-1 levels were found in GBM patients compared with those in other gliomas, which is consistent with the tissue expression levels obtained by Yamaoka et al. In another study conducted to reveal the roles of GAL-1 in glial tumor biology, malignant glioma cells with high infiltrative capacity presented higher GAL-1 expression compared to non-invasive regions [31].