While CME-induced MINOCA as well as MI demonstrated a largely analogous profile of plasma inflammatory cytokines (such as TNF-α, IL-1α and IL-1β) (Fig. 4a), differences in INF-γ (higher in MI) (Fig. 4b) and IL-10 (higher in MINOCA) (Fig. 4c) levels support the concept of distinct inflammatory responses, which require further investigation including the identification of relevant leukocyte subsets in both infarction types. The gene discussed is IL1B; the disease is myocardial infarction.