At week 52, the proportion with endoscopic remission increased to 46% in those with a disease duration of 5 years or less but remained at less than 27% in the longer disease duration groups.43 A further analysis of data from LOVE-CD stratified patients by early (< 2 years since diagnosis and treated only with corticosteroids and immunomodulators) and late (> 2 years since diagnosis and treated with corticosteroids plus immunomodulators and/or an anti-TNFα treatment) disease. This evidence concerns the gene TNF and Cowden disease.