Analyses of pressure-volume (PV) curves (Fig. S2B) revealed higher hysteresis and static compliance (Fig. S2G and H) in Scnn1b-Tg mice at baseline and 7 days after sterile agar bead inoculation (Fig. 1J through L), confirming the presence of underlying emphysema and damage to alveoli in Scnn1b-Tg mice. Here, SCNN1B is linked to pulmonary emphysema.