To test this, SCFM2-Scnn1b-Tg mice were infected with PAO1 and compared to SCFM2-C57BL/6 wild-type (WT) littermate infected mice, and we measured the effects on bacterial clearance, lung function, and immune responses to infection, using uninfected mice inoculated with sterile SCFM2 agar beads as controls. The gene discussed is SCNN1B; the disease is infection.