Using wild-type SCFM2-C57BL/6 mice as controls, SCFM2-Scnn1b-Tg mice failed to clear bacterial infections, and lung function measurements showed that infected SCFM2-Scnn1b-Tg mice had decreased inspiratory capacity and compliance, elevated airway resistance, and significantly reduced forced expiratory volumes. Here, SCNN1B is linked to bacterial infectious disease.